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Front Cover: Ion Mobility‐Enhanced Data‐Independent Acquisitions Enable a Deep Proteomic Landscape of Oligodendrocytes
Author(s) -
Cassoli Juliana S.,
BrandãoTeles Caroline,
Santana Aline G.,
Souza Gustavo H. M. F.,
MartinsdeSouza Daniel
Publication year - 2017
Publication title -
proteomics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201770161
Subject(s) - proteome , neuroscience , oligodendrocyte , central nervous system , axon , front cover , biology , chemistry , cover (algebra) , myelin , bioinformatics , mechanical engineering , engineering
DOI: 10.1002/pmic.201700209 The cover shows a 2D ion mobility map, composed by drift time x m/z. In article number 1700209, Juliana S. Cassoli et al. used ion mobility‐enhanced, data‐independent acquisitions and 2D‐nanoUPLC fractionation to describe the human oligodendrocyte proteome. Oligodendrocytes are responsible for the myelination of axon fibers in the central nervous system. Their dysfunction can lead to disturbances in myelination and consequently to deficient propagation of nerve impulses, compromising cognitive, neural, and glial functions as observed in several neurodegenerative diseases.