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Front Cover: Highly selective enrichment of phosphopeptides by on‐chip indium oxide functionalized magnetic nanoparticles coupled with MALDI‐TOF MS
Author(s) -
Jiang Dandan,
Song Naizhong,
Li Xiqian,
Ma Jiutong,
Jia Qiong
Publication year - 2017
Publication title -
proteomics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201770131
Subject(s) - magnetic nanoparticles , indium , nanoparticle , chemistry , chromatography , solid phase extraction , oxide , iron oxide nanoparticles , surface modification , extraction (chemistry) , adsorption , magnetic separation , nanotechnology , materials science , organic chemistry , metallurgy
DOI: 10.1002/pmic.201700213 In article number 1700213, Dandan Jiang et al. describe the design and application of an on‐chip system coupled magnetic solid phase extraction with MALDI‐TOF MS. A metal oxide affinity chromatography material, indium oxide, was coated on the surface of Fe 3 O 4 magnetic nanoparticles to prepare the adsorbent. The developed approach was successfully applied to analyze phosphopeptides in standard protein digests, non‐fat milk digests, and human serum.