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Front Cover: Multiplexed MRM‐based assays for the quantitation of proteins in mouse plasma and heart tissue
Author(s) -
Percy Andrew J.,
Michaud Sarah A.,
Jardim Armando,
Sinclair Nicholas J.,
Zhang Suping,
Mohammed Yassene,
Palmer Andrea L.,
Hardie Darryl B.,
Yang Juncong,
LeBlanc Andre M.,
Borchers Christoph H.
Publication year - 2017
Publication title -
proteomics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201770050
Subject(s) - front cover , biomarker , computational biology , biology , proteomics , microbiology and biotechnology , chemistry , chromatography , biochemistry , cover (algebra) , gene , mechanical engineering , engineering
DOI: 10.1002/pmic.201600097 The article describes the rigorous development and application of highly multiplexed assays for the in‐depth quantitation of 100s of proteins in mouse plasma and heart tissue samples. The method features a targeted MRM approach with stable isotope‐labeled peptides as internal standards. The validated assays have disease relevance and associations with biological/molecular processes, and are suitable for molecular phenotyping and biomarker assessment studies. For more details, see the research article by Andrew J. Percy et al., article number 1600097.