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Inside Front Cover: Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles
Author(s) -
Liem Michael,
Ang ChingSeng,
Mathivanan Suresh
Publication year - 2017
Publication title -
proteomics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.2017700182
Subject(s) - microvesicles , protein kinase b , pi3k/akt/mtor pathway , extracellular vesicles , microbiology and biotechnology , proteomics , proteome , insulin , biology , signal transduction , chemistry , bioinformatics , biochemistry , microrna , gene , endocrinology
DOI: 10.1002/pmic.201600371 The cover highlights protein‐protein interaction network that are enriched in exosomes that are secreted by PI3K/Akt signaling activated colorectal cancer cells. Stimulating colorectal cancer cells with insulin resulted in alteration of the proteomic cargo of exosomes. Network analysis highlighted the enrichment of proteins implicated in cell proliferation in exosomes secreted by cells stimulated with insulin. For more details, see the research article by Michael Liem et al., article number 1600371.