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Links between critical proteins drive the controllability of protein interaction networks
Author(s) -
Wuchty Stefan,
Boltz Toni,
KüçükMcGinty Hande
Publication year - 2017
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201700056
Subject(s) - computational biology , homo sapiens , biology , controllability , protein–protein interaction , gene , saccharomyces cerevisiae , transcription factor , phosphorylation , proteomics , microbiology and biotechnology , genetics , mathematics , sociology , anthropology
Focusing on the interactomes of Homo sapiens , Saccharomyces cerevisiae , and Escherichia coli , we investigated interactions between controlling proteins. In particular, we determined critical, intermittent, and redundant proteins based on their tendency to participate in minimum dominating sets. Independently of the organisms considered, we found that interactions that involved critical nodes had the most prominent effects on the topology of their corresponding networks. Furthermore, we observed that phosphorylation and regulatory events were considerably enriched when the corresponding transcription factors and kinases were critical proteins, while such interactions were depleted when they were redundant proteins. Moreover, interactions involving critical proteins were enriched with essential genes, disease genes, and drug targets, suggesting that such characteristics may be key for the detection of novel drug targets as well as assess their efficacy.