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Cryo‐sectioning of mice for whole‐body imaging of drugs and metabolites with desorption electrospray ionization mass spectrometry imaging – a simplified approach
Author(s) -
Okutan Seda,
Hansen Harald S.,
Janfelt Christian
Publication year - 2016
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201670113
Subject(s) - mass spectrometry imaging , mass spectrometry , chemistry , chromatography , electrospray ionization , electrospray mass spectrometry , desorption electrospray ionization , electrospray , ionization , chemical ionization , organic chemistry , ion
DOI: 10.1002/pmic.201500422 Mass spectrometry imaging can be used for highly specific tracking of several compounds in one experiment. The cover shows mass spectrometry images of a mouse dosed intraperitoneally with the antidepressive drug amitriptyline. The signal from an endogenous lipid is displayed in green, the drug is illustrated in red, and one of the drug metabolites is indicated blue. For more details, see research article by Seda Okutan, Harald S. Hansen and Christian Janfelt on page 1633.