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Proteomic profiling of extracellular vesicles secreted from Toxoplasma gondii
Author(s) -
Wowk Pryscilla Fanini,
Zardo Maria Luisa,
Miot Halisson Tesseroli,
Goldenberg Samuel,
Carvalho Paulo Costa,
Mörking Patricia Alves
Publication year - 2017
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201600477
Subject(s) - toxoplasma gondii , microvesicles , biology , immune system , extracellular , extracellular vesicles , proteomics , extracellular vesicle , microbiology and biotechnology , proteome , toxoplasmosis , context (archaeology) , nucleic acid , virology , immunology , gene , biochemistry , antibody , microrna , paleontology
Toxoplasma gondii infects a wide range of hosts worldwide, including humans and domesticated animals causing toxoplasmosis disease. Recently, exosomes, small extracellular vesicles (EV) that contain nucleic acids, proteins, and lipids derived from their original cells were linked with disease protection. The effect of EVs derived from T. gondii on the immune response and its relevance in a physiological context is unknown. Here we disclose the first proteomic profiling of T. gondii EVs compared to EVs isolated from a human foreskin fibroblast infected cell line cultured in a vesicle‐free medium. Our results reveal a broad range of canonical exosomes proteins. Data are available via ProteomeXchange with the identifier PXD004895.