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Advancing translational research with next‐generation protein microarrays
Author(s) -
Yu Xiaobo,
Petritis Brianne,
LaBaer Joshua
Publication year - 2016
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201500374
Subject(s) - protein microarray , dna microarray , translational research , proteomics , microarray , posttranslational modification , computational biology , identification (biology) , protein array analysis , biology , bioinformatics , genetics , microbiology and biotechnology , gene , gene expression , biochemistry , botany , enzyme
Protein microarrays are a high‐throughput technology used increasingly in translational research, seeking to apply basic science findings to enhance human health. In addition to assessing protein levels, posttranslational modifications, and signaling pathways in patient samples, protein microarrays have aided in the identification of potential protein biomarkers of disease and infection. In this perspective, the different types of full‐length protein microarrays that are used in translational research are reviewed. Specific studies employing these microarrays are presented to highlight their potential in finding solutions to real clinical problems. Finally, the criteria that should be considered when developing next‐generation protein microarrays are provided.