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Linking cancer genome to proteome: NCI's investment into proteogenomics
Author(s) -
Rivers Robert C.,
Kinsinger Christopher,
Boja Emily S.,
Hiltke Tara,
Mesri Mehdi,
Rodriguez Henry
Publication year - 2014
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201400193
Subject(s) - proteogenomics , proteome , computational biology , proteomics , biology , genome , genomics , cancer , human proteome project , bioinformatics , genetics , gene
Advances in both targeted and unbiased MS‐based proteomics are now at a mature stage for comprehensively and reproducibly characterizing a large part of the cancer proteome. These developments combined with the extensive genomic characterization of several cancer types by large‐scale initiatives such as the International Cancer Genome Consortium and Cancer Genome Atlas Project have paved the way for proteogenomic analysis of omics datasets and integration methods. The advances serve as the basis for the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium and this article highlights its current work and future steps in the area of proteogenomics.