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Thiol‐based redox proteomics in cancer research
Author(s) -
Yuan Kefei,
Liu Yuan,
Chen HaiNing,
Zhang Lu,
Lan Jiang,
Gao Wei,
Dou Qianhui,
Nice Edouard C.,
Huang Canhua
Publication year - 2015
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201400164
Subject(s) - proteomics , redox , oxidative stress , intracellular , function (biology) , cancer cell , microbiology and biotechnology , reactive oxygen species , biology , chemistry , biochemistry , cancer , gene , genetics , organic chemistry
Cancer cells maintain their intracellular ROS concentrations at required levels for their survival. Changes in ROS concentrations can regulate biochemical signaling mechanisms that control cell function. It has been demonstrated that ROS regulate the cellular events through redox regulation of redox‐sensitive proteins (redox sensors). Upon oxidative stress, redox sensors undergo redox modifications that cause the allosteric changes of these proteins and endow them with different functions. Understanding the altered functions of redox sensors and the underlying mechanisms is critical for the development of novel cancer therapeutics. Recently, a series of high‐throughput proteomics approaches have been developed for screening redox processes. In this manuscript, we review these methodologies and discuss the important redox sensors recently identified that are related to cancer.