Investigation of stable and transient protein–protein interactions: Past, present, and future | Zendy

Ngounou Wetie Armand G. | Zendy; Sokolowska Izabela | Zendy; Woods Alisa G. | Zendy; Roy Urmi | Zendy; Loo Joseph A. | Zendy; Darie Costel C. | Zendy

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Investigation of stable and transient protein–protein interactions: Past, present, and future

Author(s) -

Ngounou Wetie Armand G.,

Sokolowska Izabela,

Woods Alisa G.,

Roy Urmi,

Loo Joseph A.,

Darie Costel C.

Publication year - 2013

Publication title -

proteomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.26

H-Index - 167

eISSN - 1615-9861

pISSN - 1615-9853

DOI - 10.1002/pmic.201200328

Subject(s) - transient (computer programming) , focus (optics) , computational biology , proteomics , function (biology) , computer science , biology , bioinformatics , microbiology and biotechnology , biochemistry , physics , gene , optics , operating system

This article presents an overview of the literature and a review of recent advances in the analysis of stable and transient protein–protein interactions ( PPI s) with a focus on their function within cells, organs, and organisms. The significance of PTMs within the PPI s is also discussed. We focus on methods to study PPI s and methods of detecting PPI s, with particular emphasis on electrophoresis‐based and MS ‐based investigation of PPI s, including specific examples. The validation of PPI s is emphasized and the limitations of the current methods for studying stable and transient PPI s are discussed. Perspectives regarding PPI s, with focus on bioinformatics and transient PPI s are also provided.

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