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CP hos: A program to calculate and visualize evolutionarily conserved functional phosphorylation sites
Author(s) -
Zhao Boyang,
Pisitkun Trairak,
Hoffert Jason D.,
Knepper Mark A.,
Saeed Fahad
Publication year - 2012
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201200189
Subject(s) - phosphorylation , computational biology , java , computer science , biology , relevance (law) , profiling (computer programming) , mechanism (biology) , bioinformatics , database , microbiology and biotechnology , programming language , physics , political science , law , quantum mechanics
Profiling using high-throughput MS has discovered an overwhelming number of novel protein phosphorylation sites ("phosphosites"). However, the functional relevance of these sites is not always clear. In light of recent studies on the evolutionary mechanism of phosphorylation, we have developed CPhos, a Java program that can assess the conservation of phosphosites among species using an information theory-based approach. The degree of conservation established using CPhos can be used to assess the functional significance of phosphosites. CPhos has a user friendly graphical user interface and is available both as a web service and as a standalone Java application to assist phosphoproteomic researchers in analyzing and prioritizing lists of phosphosites for further experimental validation. CPhos can be accessed or downloaded at http://helixweb.nih.gov/CPhos/.