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Review on proteomic analyses of benzo[a]pyrene toxicity
Author(s) -
Verma Nisha,
Pink Mario,
Rettenmeier Albert W.,
SchmitzSpanke Simone
Publication year - 2012
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201100466
Subject(s) - benzo(a)pyrene , toxicity , proteomics , pyrene , chemistry , dna damage , carcinogen , environmental chemistry , biology , biochemistry , dna , gene , organic chemistry
Benzo[a]pyrene ( B a P ), a five‐ring polycyclic aromatic hydrocarbon, is a well‐recognized environmental pollutant. Coal‐processing waste products, petroleum sludge, asphalt, creosote, and tobacco smoke, all contain high levels of B a P . Exposure to B a P elicits many adverse biological effects, including tumor formation, immunosuppression, teratogenicity, and hormonal effects. In addition to the genetic damage caused by B a P exposure, several studies have indicated the disruption of protein–protein signaling pathways. However, contrary to the large number of studies on B a P ‐induced DNA damage, only few data have been gathered on its effects at the protein level. This review highlights all proteomic studies to date used for assessing the toxicity of B a P and its metabolites in various organ systems. It will also give an overview on the role proteomics may play to elucidate the mechanisms underlying B a P toxicity.