Proteomic analysis of the microenvironment of developing oocytes | Zendy

Twigt John | Zendy; SteegersTheunissen Regine P. | Zendy; Bezstarosti Karel | Zendy; Demmers Jeroen A. A. | Zendy

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Proteomic analysis of the microenvironment of developing oocytes

Author(s) -

Twigt John,

SteegersTheunissen Regine P.,

Bezstarosti Karel,

Demmers Jeroen A. A.

Publication year - 2012

Publication title -

proteomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.26

H-Index - 167

eISSN - 1615-9861

pISSN - 1615-9853

DOI - 10.1002/pmic.201100240

Subject(s) - proteome , oocyte , follicular fluid , fractionation , proteomics , immune system , biology , microbiology and biotechnology , chemistry , computational biology , biochemistry , immunology , chromatography , embryo , gene

We utilized a setup based on extensive pre‐fractionation of proteolytic peptides and nanoflow reversed‐phase LC ‐ MS / MS to identify the (sub)proteome of human follicular fluid ( FF ). In this in‐depth screen, 246 specific proteins were identified, the majority of which are involved in coagulation‐ and immune‐response pathways. Our aim is to define a set of FF protein markers, which could predict oocyte quality.

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