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Immune proteomics of Staphylococcus aureus
Author(s) -
Bröker Barbara M.,
van Belkum Alex
Publication year - 2011
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201100010
Subject(s) - staphylococcus aureus , proteomics , immune system , microbiology and biotechnology , biology , computational biology , immunology , bacteria , genetics , gene
Immune proteomics is an increasingly powerful tool for the investigation of the adaptive immune response to natural encounters between micro‐organisms and their hosts. The versatile species Staphylococcus aureus serves to illustrate how these techniques can be employed to appreciate the complexity and diversity of the host–pathogen interactions in unprecedented detail and completeness. Such knowledge is important for the development of effective vaccines as well as informative diagnostic and novel therapeutic tools. From high‐resolution immune proteome studies, general rules underlying the human adaptive immune response to S. aureus colonization and infection are beginning to emerge against a background of extreme diversity: S. aureus carriers develop immune memory for their colonizing strain, but even non‐carriers are frequently exposed to S. aureus, resulting in specific antibodies. During bacterial invasion, immune‐competent individuals rapidly mount an antibody response to a large panel of S. aureus antigens. However, every patient starts from a personal baseline antibody profile reflecting his or her history of encounters with S. aureus .