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Proteomics of corynebacteria: From biotechnology workhorses to pathogens
Author(s) -
Poetsch Ansgar,
Haußmann Ute,
Burkovski Andreas
Publication year - 2011
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201000786
Subject(s) - corynebacterium glutamicum , proteomics , biology , actinobacteria , proteome , corynebacterium , bacteria , microbiology and biotechnology , nocardia , pathogenic bacteria , mycobacterium , computational biology , bioinformatics , biochemistry , 16s ribosomal rna , genetics , gene
Abstract Corynebacteria belong to the high G+C Gram‐positive bacteria (Actinobacteria) and are closely related to Mycobacterium and Nocardia species. The best investigated member of this group of almost seventy species is Corynebacterium glutamicum , a soil bacterium isolated in 1957, which is used for the industrial production of more than two million tons of amino acids per year. This review focuses on the technical advances made in proteomics approaches during the last years and summarizes applications of these techniques with respect to C. glutamicum metabolic pathways and stress response. Additionally, selected proteome applications for other biotechnologically important or pathogenic corynebacteria are described.