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Renal fibrosis: Insight from proteomics in animal models and human disease
Author(s) -
Klein Julie,
Kavvadas Panagiotis,
Prakoura Niki,
Karagianni Fani,
Schanstra Joost P.,
Bascands JeanLoup,
Charonis Aristidis
Publication year - 2011
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201000380
Subject(s) - fibrosis , disease , kidney disease , medicine , bioinformatics , proteomics , identification (biology) , intensive care medicine , pathology , biology , botany , biochemistry , gene
Chronic kidney disease (CKD) is the end‐point of a number of renal and systemic diseases. The high incidence and financial burden of CKD makes it imperative to diagnose CKD at early stages when therapeutic interventions are far more effective. A key component of CKD is the development of renal fibrosis. Renal fibrosis is a complex process, associated with many cell types and pathways, resulting in structural and functional alterations. Identification of specific biomarkers of renal fibrosis may thus not only help us to understand the pathophysiological mechanisms involved in this process, but also improve diagnosis in the clinic. In this review, the existing literature on proteomic approaches to study renal fibrosis is presented and evaluated. The importance of using animal models along with patient material is discussed and future directions, considered key to this field, are proposed.