The effect of interfering ions on search algorithm performance for electron‐transfer dissociation data | Zendy

Good David M. | Zendy; Wenger Craig D. | Zendy; Coon Joshua J. | Zendy

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The effect of interfering ions on search algorithm performance for electron‐transfer dissociation data

Author(s) -

Good David M.,

Wenger Craig D.,

Coon Joshua J.

Publication year - 2009

Publication title -

proteomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.26

H-Index - 167

eISSN - 1615-9861

pISSN - 1615-9853

DOI - 10.1002/pmic.200900570

Subject(s) - electron transfer dissociation , mascot , dissociation (chemistry) , mass spectrometry , database search engine , computer science , ion , search algorithm , chemistry , electron transfer , algorithm , search engine , tandem mass spectrometry , information retrieval , chromatography , photochemistry , organic chemistry , political science , law

Collision‐activated dissociation and electron‐transfer dissociation (ETD) each produce spectra containing unique features. Though several database search algorithms ( e.g. SEQUEST, MASCOT, and Open Mass Spectrometry Search Algorithm) have been modified to search ETD data, this consists chiefly of the ability to search for c ‐ and z • ‐ions; additional ETD‐specific features are often unaccounted for and may hinder identification. Removal of these features via spectral processing increased total search sensitivity by ∼20% for both human and yeast data sets; unique peptide identifications increased by ∼17% for the yeast data sets and ∼16% for the human data set.

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