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The secreted proteome profile of developing Dictyostelium discoideum cells
Author(s) -
Bakthavatsalam Deenadayalan,
Gomer Richard H.
Publication year - 2010
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200900516
Subject(s) - dictyostelium discoideum , dictyostelium , eukaryote , proteome , multicellular organism , biology , proteomics , proteolysis , gene , mycetozoa , biochemistry , genome , microbiology and biotechnology , enzyme
Dictyostelium discoideum is a unicellular eukaryote that, when starved, aggregates to form multicellular structures. In this report, we identified the proteins secreted by developing Dictyostelium cells using MS‐based proteomics. A total of 349 different secreted proteins were identified, indicating that at least 2.6% of the 13 600 predicted proteins in the Dictyostelium genome are secreted. Gene ontology analysis suggests that many of the secreted proteins are involved in protein and carbohydrate metabolism, and proteolysis.