Cover Picture: Proteomics 4/2008

Cover Illustration: The image in the large circle shows a multiprotein signaling complex, in which the receptor dimer is localized to a plasma membrane microdomain (in red). The pictures in the small circles show commonly used proteomic approaches to the analysis of signaling complexes: 1) P urification; 2) R efinement of individual components; 3) Quan T i T a T ive analysis; 4) Identification of post‐translational M odifications; and 5) C ross‐linking. The bold letters in the above‐mentioned approaches constitute the consonants of the word PROTEOMIC, which can further compose the word PROTEOMICS with the initial letter of S ignaling complexes. For further details, see the article by Yang et al. , Proteomics 2008, 8, 832–851 (in this issue).