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A method based on bead flows for spot detection on 2‐D gel images
Author(s) -
Langella Olivier,
Zivy Michel
Publication year - 2008
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200800644
Subject(s) - smoothing , bead , image (mathematics) , spots , resolution (logic) , artificial intelligence , computer vision , computer science , chromatography , pattern recognition (psychology) , chemistry , materials science , composite material
A method has been developed to detect spots on 2‐D gel images. It is based on an analogy with beads flowing uphill on the surface of the gel image and on the analysis of their paths. This method does not need image smoothing, thereby allowing for conservation of the resolution of the original image. In addition, it allows for the detection of overlapping spots, even when there is no valley between their centres.