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Biomarker discovery in asthma‐related inflammation and remodeling
Author(s) -
Calvo Florence Quesada,
Fillet Marianne,
de Seny Dominique,
Meuwis MarieAlice,
Maree Raphael,
Crahay Céline,
Paulissen Geneviève,
Rocks Natacha,
Gueders Maud,
Wehenkel Louis,
Merville MariePaule,
Louis Renaud,
Foidart JeanMichel,
Noël Agnes,
Cataldo Didier
Publication year - 2009
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200800643
Subject(s) - inflammation , extracellular matrix , asthma , proteases , biomarker , immunology , proteomics , chemistry , biology , microbiology and biotechnology , biochemistry , enzyme , gene
Asthma is a complex inflammatory disease of airways. A network of reciprocal interactions between inflammatory cells, peptidic mediators, extracellular matrix components, and proteases is thought to be involved in the installation and maintenance of asthma‐related airway inflammation and remodeling. To date, new proteic mediators displaying significant activity in the pathophysiology of asthma are still to be unveiled. The main objective of this study was to uncover potential target proteins by using surface‐enhanced laser desorption/ionization‐time of flight‐mass spectrometry (SELDI‐TOF‐MS) on lung samples from mouse models of allergen‐induced airway inflammation and remodeling. In this model, we pointed out several protein or peptide peaks that were preferentially expressed in diseased mice as compared to controls. We report the identification of different five proteins: found inflammatory zone 1 or RELMα (FIZZ‐1), calcyclin (S100A6), clara cell secretory protein 10 (CC10), Ubiquitin, and Histone H4.