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The post‐translational modification profile of the forkhead transcription factor FOXL2 suggests the existence of parallel processive/concerted modification pathways
Author(s) -
Benayoun Bérénice A.,
Auer Jana,
Caburet Sandrine,
Veitia Reiner A.
Publication year - 2008
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200800084
Subject(s) - subfamily , transcription factor , posttranslational modification , forkhead transcription factors , microbiology and biotechnology , biology , chemical modification , genetics , chemistry , computational biology , biochemistry , enzyme , gene
The transcription factor Forkhead box L subfamily member 2 (FOXL2) is involved in craniofacial development and ovarian function. Using 2‐DE and immunoblotting, we show that it is highly modified post‐translationally. The most outstanding feature of its migration profile is the presence of two distinct modification “trains” and the absence of intermediates. A theoretical analysis of the modification profile of FOXL2 suggests that it undergoes parallel processive/concerted modifications. The absence of intermediates is compatible with the recruitment of poorly modified FOXL2 into a post‐translational “modification factory.”