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Phosphoproteomics, oncogenic signaling and cancer research
Author(s) -
Chong PohKuan,
Lee Huiyin,
Kong Jacklyn WaiFun,
Loh Marie ChiewShia,
Wong CheeHong,
Lim YoonPin
Publication year - 2008
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200800051
Subject(s) - phosphoproteomics , computational biology , phosphorylation , biology , cancer , identification (biology) , proteomics , tyrosine kinase , signal transduction , bioinformatics , protein phosphorylation , microbiology and biotechnology , genetics , protein kinase a , gene , botany
Abstract The past 5 years have seen an explosion of phosphoproteomics methods development. In this review, using epidermal growth‐factor signaling as a model, we will discuss how phosphoproteomics, along with bioinformatics and computational modeling, have impacted key aspects of oncogenic signaling such as in the temporal fine mapping of phosphorylation events, and the identification of novel tyrosine kinase substrates and phosphorylation sites. We submit that the next decade will see considerable exploitation of phosphoproteomics in cancer research. Such a phenomenon is already happening as exemplified by its use in promoting the understanding of the molecular etiology of cancer and target‐directed therapeutics.