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Characterization of microRNA‐regulated protein‐protein interaction network
Author(s) -
Hsu ChunWei,
Juan HsuehFen,
Huang HsuanCheng
Publication year - 2008
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200701004
Subject(s) - microrna , modularity (biology) , interaction network , computational biology , protein–protein interaction , biology , gene , genetics
Abstract We have performed topological analysis to elucidate the global correlation between microRNA (miRNA) regulation and protein‐protein interaction network in human. The analysis showed that target genes of individual miRNA tend to be hubs and bottlenecks in the network. While proteins directly regulated by miRNA might not form a network module themselves, the miRNA‐target genes and their interacting neighbors jointly showed significantly higher modularity. Our findings shed light on how miRNA may regulate the protein interaction network.