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MPA: A multiple peak alignment algorithm to perform multiple comparisons of liquid‐phase proteomic profiles
Author(s) -
Toppo Stefano,
Roveri Antonella,
Vitale Maria Pia,
Zaccarin Mattia,
Serain Elena,
Apostolidis Emanuele,
Gion Massimo,
Maiorino Matilde,
Ursini Fulvio
Publication year - 2008
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200700776
Subject(s) - pairwise comparison , computer science , algorithm , data mining , artificial intelligence
Present proteomic studies increasingly address experimental strategies focused on multiple comparisons of proteomic profiles. To accomplish semiautomatic protein separations based on 2-D LC, the Beckman Coulter PF2D has been developed. Here, we present a novel general purpose tool called MPA (multiple peak alignment) able to perform multiple comparisons of proteomic profiles both in a pairwise guided fashion and in a fully automatic mode using a strategy based on dynamic programing and progressive alignment of time series. The tool is available at http://grup.cribi.unipd.it/people/stefano/mpa/.