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Photogenerated glycan arrays identify immunogenic sugar moieties of Bacillus anthracis exosporium
Author(s) -
Wang Deg,
Carroll Gregory T.,
Turro Nicholas J.,
Koberstein Jeffrey T.,
Kováč Pavol,
Saksena Rina,
Adamo Roberto,
Herzenberg Leonore A.,
Herzenberg Leonard A.,
Steinman Lawrence
Publication year - 2007
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200600478
Subject(s) - bacillus anthracis , glycan , spore , microbiology and biotechnology , pathogen , tetrasaccharide , antibody , chemistry , monoclonal antibody , biology , biochemistry , glycoprotein , bacteria , immunology , polysaccharide , genetics
Using photogenerated glycan arrays, we characterized a large panel of synthetic carbohydrates for their antigenic reactivities with pathogen‐specific antibodies. We discovered that rabbit IgG antibodies elicited by Bacillus anthracis spores specifically recognize a tetrasaccharide chain that decorates the outermost surfaces of the B. anthracis exosporium. Since this sugar moiety is highly specific for the spores of B. anthracis , it appears to be a key biomarker for detection of B. anthracis spores and development of novel vaccines that target anthrax spores.