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Developmental vitamin D deficiency alters brain protein expression in the adult rat: Implications for neuropsychiatric disorders
Author(s) -
Almeras Lionel,
Eyles Darryl,
Benech Philippe,
Laffite Daniel,
Villard Claude,
Patatian Angela,
Boucraut Jose,
MackaySim Alan,
McGrath John,
Féron François
Publication year - 2007
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200600392
Subject(s) - vitamin d and neurology , vitamin d deficiency , schizophrenia (object oriented programming) , endocrinology , prefrontal cortex , medicine , hippocampus , biology , vitamin , neuroscience , psychiatry , cognition
An increased risk for multiple sclerosis and schizophrenia is observed at increasing latitude and in patients born in winter or spring. To explore a possible link between maternal vitamin D deficiency and these brain disorders, we examined the impact of prenatal hypovitaminosis D on protein expression in the adult rat brain. Vitamin D‐deficient female rats were mated with vitamin D normal males. Pregnant females were kept vitamin D‐deficient until birth whereupon they were returned to a control diet. At week 10, protein expression in the progeny's prefrontal cortex and hippocampus was compared with control animals using silver staining 2‐D gels associated with MS and newly devised data mining software. Developmental vitamin D (DVD) deficiency caused a dysregulation of 36 brain proteins involved in several biological pathways including oxidative phosphorylation, redox balance, cytoskeleton maintenance, calcium homeostasis, chaperoning, PTMs, synaptic plasticity and neurotransmission. A computational analysis of these data revealed that (i) nearly half of the molecules dysregulated in our animal model have also been shown to be misexpressed in either schizophrenia and/or multiple sclerosis and (ii) an impaired synaptic network may be a consequence of mitochondrial dysfunction.