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HUPO Brain Proteome Project: Summary of the pilot phase and introduction of a comprehensive data reprocessing strategy
Author(s) -
Hamacher Michael,
Apweiler Rolf,
Arnold Georg,
Becker Albert,
Blüggel Martin,
Carrette Odile,
Colvis Christine,
Dunn Michael J.,
Fröhlich Thomas,
Fountoulakis Michael,
van Hall André,
Herberg Friedrich,
Ji Juango,
Kretzschmar Hans,
Lewczuk Piotr,
Lubec Gert,
Marcus Katrin,
Martens Lennart,
Palacios Bustamante Nadine,
Park Young Mok,
Pennington Stephen R.,
Robben Johan,
Stühler Kai,
Reidegeld Kai A.,
Riederer Peter,
Rossier Jean,
Sanchez JeanCharles,
Schrader Michael,
Stephan Christian,
Tagle Danilo,
Thiele Herbert,
Wang Jing,
Wiltfang Jens,
Yoo Jong Shin,
Zhang Chenggang,
Klose Joachim,
Meyer Helmut E.
Publication year - 2006
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200600295
Subject(s) - workflow , human proteome project , proteome , relevance (law) , data science , computer science , computational biology , proteomics , bioinformatics , biology , political science , database , biochemistry , law , gene
The Human Proteome Organisation (HUPO) initiated several projects focusing on the proteome analysis of distinct human organs. The Brain Proteome Project (BPP) is the initiative dedicated to the brain, its development and correlated diseases. Two pilot studies have been performed aiming at the comparison of techniques, laboratories and approaches. With the help of the results gained, objective data submission, storage and reprocessing workflow have been established. The biological relevance of the data will be drawn from the inter‐laboratory comparisons as well as from the re‐calculation of all data sets submitted by the different groups. In the following, results of the single groups as well as the centralised reprocessing effort will be summarised and compared, showing the added value of this concerted work.