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Proteomic knowledge of human aquaporins
Author(s) -
Magni Fulvio,
Sarto Cecilia,
Ticozzi Davide,
Soldi Monica,
Bosso Niccolò,
Mocarelli Paolo,
Kienle Marzia Galli
Publication year - 2006
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200600212
Subject(s) - aquaporin , computational biology , aquaporin 1 , biology , proteomics , peptide sequence , water transport , aquaporin 2 , genome , protein family , water channel , bioinformatics , gene , biochemistry , mechanical engineering , water flow , environmental engineering , engineering , inlet
Aquaporins (AQPs) are an ubiquitous family of proteins characterized by sequence similarity and the presence of two NPA (Asp‐Pro‐Ala) motifs. At present, 13 human AQPs are known and they are divided into two subgroups according to their ability to transport only water molecules (AQP0, AQP1, AQP2, AQP4, AQP5, AQP6, and AQP8), or also glycerol and other small solutes (AQP3, AQP7, AQP9, AQP10, AQP12). The genomic, structural, and functional aspects of this family are briefly described. In particular, proteomic approaches to identify and characterize the most studied AQPs, mainly through SDS‐PAGE followed by MS analysis, are discussed. Moreover, the clinical importance of the best studied aquaporin (AQP1) in human diseases is also provided.