Premium
The number of genes changing expression after chronic exposure to Code Division Multiple Access or Frequency DMA radiofrequency radiation does not exceed the false‐positive rate
Author(s) -
Whitehead Timothy D.,
Moros Eduardo G.,
Brownstein Bernard H.,
Roti Roti Joseph L.
Publication year - 2006
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200600051
Subject(s) - gene expression , microarray , microarray analysis techniques , gene , false positive paradox , radiation exposure , gene expression profiling , andrology , microbiology and biotechnology , biology , pathology , medicine , nuclear medicine , genetics , machine learning , computer science
Experiments with cultured C3H 10T 1/2 cells were performed to determine if exposure to cell phone radiofrequency (RF) radiations induce changes in gene expression. Following a 24 h exposure of 5 W/kg specific adsorption rate, RNA was extracted from the exposed and sham control cells for microarray analysis on Affymetrix U74Av2 Genechips. Cells exposed to 0.68 Gy of X‐rays with a 4‐h recovery were used as positive controls. The number of gene expression changes induced by RF radiation was not greater than the number of false positives expected based on a sham versus sham comparison. In contrast, the X‐irradiated samples showed higher numbers of probe sets changing expression level than in the sham versus sham comparison.