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Applications of highly sensitive phosphopeptide derivatization methods without the need for organic solvents
Author(s) -
Reinders Joerg,
Meyer Helmut E.,
Sickmann Albert
Publication year - 2006
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200500494
Subject(s) - phosphopeptide , serine , phosphorylation , derivatization , threonine , chemistry , biochemistry , enzyme , protein phosphorylation , amino acid residue , chromatography , mass spectrometry , peptide sequence , protein kinase a , gene
Detection and identification of phosphorylated amino acid residues is still one of the most challenging tasks in contemporary protein analysis. Especially serine‐ and threonine‐phosphorylation is very often involved in the regulation of enzyme activities and regulates key functions in cellular processes.