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Comparison of the Paul ion trap to the linear ion trap for use in global proteomics
Author(s) -
Riter Leah S.,
Gooding Karen M.,
Hodge Barry D.,
Julian Randall K.
Publication year - 2006
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200500477
Subject(s) - quadrupole ion trap , ion trap , trap (plumbing) , proteomics , ion , identification (biology) , top down proteomics , chemistry , mass spectrometry , chromatography , analytical chemistry (journal) , physics , tandem mass spectrometry , selected reaction monitoring , biology , biochemistry , botany , organic chemistry , meteorology , gene
A critical evaluation of the performance of a 2‐D linear ion trap (IT) instrument to two 3‐D quadrupole IT instruments with emphasis on identification of rat serum proteins by bottom‐up LC‐MS/MS is presented. The speed and sensitivity of each of the instruments were investigated, and the effects that each of these have on the bottom‐up proteomics identification approach are discussed.