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Proteomic analysis of pathogenic bacterium Vibrio vulnificus
Author(s) -
Lee Ah Young,
Park Sung Goo,
Jang Mi,
Cho Sayeon,
Myung Pyung Keun,
Kim Young Ran,
Rhee Joon Haeng,
Lee Do Hee,
Park Byoung Chul
Publication year - 2006
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200500393
Subject(s) - vibrio vulnificus , virulence , proteome , biology , mutant , microbiology and biotechnology , bacteria , proteomics , genetics , gene
In this study we have constructed a proteome reference map of the pathogenic bacterium Vibrio vulnificus . From the reference map, we identified several virulence‐related proteins, such as ToxR and ToxS, as well as numerous proteins involved in diverse cellular functions. To search for additional virulence‐related proteins, we compared the whole proteomes from the wild‐type and toxR mutant of V. vulnificus and found that several proteins were up‐ or down‐regulated in the toxR mutant. We suggest that these differentially regulated proteins whose expression is coordinately controlled by a virulence regulator ToxR, some of which are already implicated in virulence, play roles in the pathogenesis of V. vulnificus .