Premium
Effects of oral vitamin C supplementation in hemodialysis patients: A proteomic assessment
Author(s) -
Weissinger Eva M.,
NguyenKhoa Thao,
Fumeron Christine,
Saltiel Claudine,
Walden Michael,
Kaiser Thorsten,
Mischak Harald,
Drüeke Tilman B.,
Lacour Bernard,
Massy Ziad A.
Publication year - 2006
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200500210
Subject(s) - hemodialysis , oxidative stress , dialysis , medicine , vitamin , vitamin c , proteomics , proteome , inflammation , endocrinology , bioinformatics , biochemistry , chemistry , biology , gene
Evidence indicates that oxidative stress is present in dialysis patients, and is associated with vitamin C deficiency. Limited data are available regarding the effects of vitamin C supplementation on oxidative stress and inflammation markers in these patients. Moreover, there are no data available on plasma polypeptide fingerprints by proteome analysis before and after vitamin C supplementation. Therefore, we analyzed plasma samples from a prospective, randomized, open‐labeled trial to assess the effects of oral vitamin C supplementation (250 mg three times per week), to define the plasma polypeptide pattern in hemodialysis patients. Our results reveal that more than 30 polypeptides show significant changes in the dialysis patients in comparison to controls with normal renal function, and that several polypeptides are affected/normalized by oral vitamin C supplementation. These results underline the remarkable potential for proteomics to recognize specific peptide profiles in different pathological situations, which might not be detected by classical methods.