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Cooperative evolution in protein complexes of yeast from comparative analyses of its interaction network
Author(s) -
Vergassola Massimo,
Vespignani Alessandro,
Dujon Bernard
Publication year - 2005
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200401138
Subject(s) - kluyveromyces lactis , yarrowia , debaryomyces hansenii , yeast , coevolution , kluyveromyces , biology , saccharomyces cerevisiae , candida glabrata , protein–protein interaction , computational biology , genetics , evolutionary biology , candida albicans
A comparative analysis among Saccharomyces cerevisiae and the other four yeasts Candida glabrata , Kluyveromyces lactis , Debaryomyces hansenii , and Yarrowia lipolytica is presented. The broad evolutionary range spanned by the organisms allows to quantitatively demonstrate novel evolutionary effects in protein complexes. The evolution rates within cliques of interlinked proteins are found to bear strong multipoint correlations, witnessing a cooperative coevolution of complex subunits. The coevolution is found to be largely independent of the tendency of the subunits to have similar abundances.