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Helicobacter pylori immunoproteomes in case reports of rosacea and chronic urticaria
Author(s) -
Mini Roberta,
Figura Natale,
D'Ambrosio Chiara,
Braconi Daniela,
Bernardini Giulia,
Di Simplicio Francesca,
Lenzi Cristina,
Nuti Ranuccio,
Trabalzini Lorenza,
Martelli Paola,
Bovalini Lucia,
Scaloni Andrea,
Santucci Annalisa
Publication year - 2005
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200401094
Subject(s) - rosacea , helicobacter pylori , immunology , pathogenesis , immunoglobulin e , immune system , chronic urticaria , medicine , helicobacter pylori infection , antibody , biology , dermatology , gastroenterology , acne
Rosacea and chronic urticaria are two common skin disorders existing in idiopathic forms. A role of Helicobacter pylori bacterium infection in the aetiopathogenesis of rosacea or chronic urticaria has been suggested although still controversial. The aim of the present study was to establish a relationship between H. pylori infection and rosacea chronic urticaria by means of an immunoproteomic investigation. We analyzed immunoglobulin A (IgA)‐, IgG‐, and IgE‐mediated immune‐responses against H. pylori antigens and we identified some bacterial immunoresponsive proteins. A general IgA‐ and IgE‐mediated immune response against antioxidative bacterial proteins was observed. A correlation between the bacterial occurrence and skin diseases pathogenesis is discussed.