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Towards a proteomic definition of CoArtem action in Plasmodium falciparum malaria
Author(s) -
Makanga Michael,
Bray Patrick G.,
Horrocks Paul,
Ward Stephen A.
Publication year - 2005
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200401076
Subject(s) - lumefantrine , malaria , plasmodium falciparum , proteome , drug , pharmacology , drug action , medicine , biology , computational biology , bioinformatics , immunology , artemisinin
We have adopted a proteomic strategy to investigate the actions of the two active components of the new antimalarial CoArtem, artemether and lumefantrine, following pharmacologically relevant drug exposure in the human malaria parasite Plasmodium falciparum . Both drugs induced profound alterations in the parasite's proteome. Moreover, the pattern of proteome alteration was specific for the drug used. The two drugs induced opposing effects on key glycolytic enzymes while exerting similar influence of the expression of stress response proteins. These initial results demonstrate the power of this approach in the study of pleiomorphic mechanisms of drug action.