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The use of proteomics in the discovery of serum biomarkers from patients with severe acute respiratory syndrome
Author(s) -
Ren Yi,
He QingYu,
Fan Jianqing,
Jones Brian,
Zhou Yuan,
Xie Yi,
Cheung ChungYan,
Wu Adrian,
Chiu JenFu,
Peiris J. S. Malik,
Tam Paul Kwong Hang
Publication year - 2004
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200400897
Subject(s) - proteomics , medicine , biomarker discovery , respiratory system , intensive care medicine , bioinformatics , computational biology , biology , biochemistry , gene
Severe acute respiratory syndrome (SARS) is a new infectious disease with a global impact. Understanding its pathogenesis and developing specific diagnostic methods for its early diagnosis are crucial for the effective management and control of this disease. By using proteomic technology, truncated forms of α 1 ‐antitrypsin (TF‐α 1 ‐AT) were found to increase significantly and consistently in sera of SARS patients compared to control subjects. The result showed a sensitivity of 100% for SARS patients and a specificity of 92.8% for controls. Furthermore, the levels of these proteins significantly correlated with certain clinico‐pathological parameters. The dramatic increase in TF‐α 1 ‐AT may be the result of degradation of α 1 ‐AT. As α 1 ‐AT plays an important role in the protection of lung function, its degradation may be an important factor in the pathogenesis of SARS. These findings indicate that increased TF‐α 1 ‐AT may be therapeutically relevant, and may also be a useful biological marker for the diagnosis of SARS.