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Fine‐tuning the prediction of sequences cleaved by signal peptidase II: A curated set of proven and predicted lipoproteins of Escherichia coli K‐12
Author(s) -
Gonnet Pedro,
Rudd Kenneth E.,
Lisacek Frédérique
Publication year - 2004
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200300749
Subject(s) - proteome , escherichia coli , complement (music) , computational biology , set (abstract data type) , biology , biochemistry , chemistry , computer science , complementation , programming language , gene , phenotype
A curated set of 81 proven and 44 predicted lipoproteins of Escherichia coli K‐12 was defined with the combined use of a literature survey, a variety of predictive tools and human expertise. The well‐documented Gram‐negative proteome of E. coli K‐12 was chosen to assess how the different approaches complement each other and to ensure a stable definition of a consistent set of lipoproteins. The results of detailed analysis of such proteins at the level of a single proteome are presented, corroborated and rationalized.