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Brain proteome of mice lacking the receptors for tumor necrosis factor α
Author(s) -
Pejović Vojislav,
Šoškić Vukić,
Pan Weihong,
Kastin Abba J.
Publication year - 2004
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200300687
Subject(s) - receptor , tumor necrosis factor alpha , signal transduction , proteome , microbiology and biotechnology , biology , immunology , biochemistry
Tumor necrosis factor α (TNFα) is involved in regulation of food intake, inflammatory response, and cancer cachexia. Its actions are mediated by at least two receptors: TNFR1 and TNFR2. We show that mice lacking the TNFα receptors have altered levels of proteins that take part in signal transduction, stress response, protein folding, glucose and amino acid metabolism, vesicle trafficking, and cytoskeletal arrangements. This is the first time that some of them have been associated with TNFα signaling pathways.