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Protein arrays for autoantibody profiling and fine‐specificity mapping
Author(s) -
Robinson William H.,
Steinman Lawrence,
Utz Paul J.
Publication year - 2003
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.200300583
Subject(s) - autoantibody , epitope , computational biology , epitope mapping , autoimmunity , autoimmune disease , proteomics , antigen , biology , immunology , antibody , genetics , gene
Protein arrays provide a powerful approach to study autoimmune disease. Autoimmune responses activate B cells to produce autoantibodies that recognize self‐molecules termed autoantigens, many of which are proteins or protein complexes. Protein arrays enable profiling of the specificity of autoantibody responses against panels of peptides and proteins representing known autoantigens as well as candidate autoantigens. In addition to identifying autoantigens and mapping immunodominant epitopes, proteomic analysis of autoantibody responses will further enable diagnosis, prognosis, and tailoring of antigen‐specific tolerizing therapy.