Open AccessControlled release systems based on polyacrylates and polyacrylates/clay nanocomposites of atenolol drug
Author(s) -
Akelah Ahmed,
Rehab Ahmed
Publication year - 2022
Publication title -
spe polymers
Language(s) - English
Resource type - Journals
ISSN - 2690-3857
DOI - 10.1002/pls2.10070
Subject(s) - atenolol , montmorillonite , copolymer , acrylate , monomer , intercalation (chemistry) , drug delivery , materials science , nanocomposite , drug , chemical engineering , controlled release , chemistry , polymer chemistry , polymer , organic chemistry , nanotechnology , pharmacology , medicine , blood pressure , engineering , radiology
Atenolol‐polyacrylate and intercalated atenolol‐polyacrylate onto montmorillonite clay was synthesized as drug delivery systems. The synthesis was carried out by free radical homo and copolymerization of acrylate drug (atenolol) monomer with different co‐monomers. The intercalation of polymeric drug systems onto montmorillonite clay was achieved through ion exchange process. The characterization of the prepared systems was investigated by different analytical techniques. The release studies of drug (atenolol) were studied over a long time in aqueous mediums at conditions nearly present in human body.