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P( MMA‐ co ‐HPMA )‐ b ‐POEGMA copolymers: synthesis, micelle formation in aqueous media and drug encapsulation
Author(s) -
Selianitis Dimitrios,
Pispas Stergios
Publication year - 2021
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.6229
Subject(s) - copolymer , amphiphile , micelle , polymer chemistry , methacrylate , polymerization , chain transfer , dynamic light scattering , monomer , methyl methacrylate , ethylene glycol , materials science , aqueous solution , chemistry , organic chemistry , radical polymerization , polymer , nanoparticle , nanotechnology
We report the synthesis and the micellar self‐assembly in aqueous media of novel amphiphilic block copolymers. The copolymers consist of a poly[(methyl methacrylate)‐ co ‐(hydroxypropyl methacrylate)] statistical copolymer block and a poly[oligo(ethylene glycol) methyl ether methacrylate] block, and were synthesized by reversible addition–fragmentation chain transfer polymerization. The amphiphilic P(MMA‐ co ‐HPMA)‐ b ‐POEGMA block copolymers contain monomers of differing polarity and in varying ratios. Furthermore, HPMA segments are chosen in order to enhance hydrogen bonding interactions within the core of spherical micelles formed by the copolymers in aqueous media, as evidenced by light scattering and fluorescence spectroscopy studies. The amphiphilic copolymers are able to encapsulate the hydrophobic drugs curcumin and indomethacin as found using light scattering and spectroscopic methods. © 2021 Society of Industrial Chemistry.