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Immobilization of amikacin on dextran: biocomposite materials that release an antibiotic in the presence of bacterial dextranase
Author(s) -
Dyatlov Valerie,
Seregina Tatiana,
Luss Anna,
Zaitsev Vladimir,
Artyukhov Alexander,
Shtilman Mikhail,
Chumakova Anna,
Kushnerev Kirill,
Tsatsakis Aristidis,
Mezhuev Yaroslav
Publication year - 2021
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.6171
Subject(s) - amikacin , dextran , biocomposite , epichlorohydrin , dextranase , chemistry , materials science , microbiology and biotechnology , polymer chemistry , antibiotics , biochemistry , composite material , biology , composite number
The immobilization of a broad‐spectrum antibiotic amikacin on macromolecules of dextran previously modified with epichlorohydrin is described. It is shown that the release of amikacin is observed only in the presence of dextranase, which is produced by bacteria. For the first time, biocomposite materials based on the Glisson capsule of the liver and the pericardium, containing a layer of grafted dextran acting as a carrier of amikacin and capable of releasing amikacin derivatives that have antibacterial activity in the case of infection, have been developed. It was found that the release rate of amikacin derivatives formed in the presence of dextranase is determined by diffusion and is inversely proportional to the squared thickness of the dextran‐containing layer on the surface of biocomposite materials. © 2020 Society of Chemical Industry