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Novel pranoprofen‐poly(ε‐caprolactone) conjugates: microwave‐assisted synthesis and structural characterization
Author(s) -
Impallomeni Giuseppe,
Mineo Placido Giuseppe,
Vento Fabiana,
Ballistreri Alberto
Publication year - 2021
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.6141
Subject(s) - caprolactone , drug delivery , polymer , conjugate , gel permeation chromatography , chemistry , covalent bond , materials science , combinatorial chemistry , organic chemistry , polymerization , mathematical analysis , mathematics
Biodegradable polymers are used in many biomedical devices, such as implants, cellular scaffolds and drug delivery systems. To improve drug delivery capability and to reduce systemic toxicity, the interest in polymer–drug conjugates has increased remarkably. With this aim, pranoprofen (PPF) (an effective non‐steroidal anti‐inflammatory drug used mainly in ophthalmology) was conjugated to poly(ε‐caprolactone) (PCL) via microwave‐assisted transesterification, acid‐catalyzed by p ‐toluenesulfonic acid. The products obtained were characterized by NMR, matrix assisted laser desorption ionization time of flight mass spectrometry, gel permeation chromatography (which gave proof of the covalent link between PPF and PCL) and thermal analyses. The conjugates were found to contain up to 4.3% w/w of PPF and had molecular weights ranging from 5 to 12 kDa. © 2020 Society of Industrial Chemistry