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PEGylated hollow pH‐responsive polymeric nanocapsules for controlled drug delivery
Author(s) -
Massoumi Bakhshali,
Abbasian Mojtaba,
JahanbanEsfahlan Rana,
Motamedi Sanaz,
Samadian Hadi,
Rezaei Aram,
Derakhshankhah Hossein,
FarnudiyanHabibi Amir,
Jaymand Mehdi
Publication year - 2020
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5987
Subject(s) - ethylene glycol , nanocapsules , doxorubicin hydrochloride , materials science , drug delivery , nanoparticle , copolymer , click chemistry , peg ratio , methacrylate , nuclear chemistry , polymer chemistry , chemical engineering , polymer , chemistry , nanotechnology , doxorubicin , organic chemistry , engineering , medicine , surgery , finance , chemotherapy , economics , composite material
Novel pH‐responsive PEGylated hollow nanocapsules (HNCaps) were fabricated through a combination of distillation–precipitation copolymerization and surface thiol–ene ‘click’ grafting reaction. For this purpose, SiO 2 nanoparticles were synthesized using the Stöber approach, and then modified using 3‐(trimethoxysilyl)propyl methacrylate (MPS). Afterward, a mixture of triethyleneglycol dimethacrylate (as crosslinker), acrylic acid (AA; as pH‐responsive monomer) and MPS‐modified SiO 2 nanoparticles (as sacrificial template) was copolymerized using the distillation–precipitation approach to afford SiO 2 @PAA core–shell nanoparticles. The SiO 2 core was etched from SiO 2 @PAA using HF solution, and the obtained PAA HNCaps were grafted with a thiol‐end‐capped poly(ethylene glycol) (PEG) through a thiol–ene ‘click’ reaction to produce PAA‐ g ‐PEG HNCaps. The fabricated HNCaps were loaded with doxorubicin hydrochloride (DOX) as a model anticancer drug, and their drug loading and encapsulation efficiencies as well as pH‐dependent drug release behavior were investigated. The anticancer activity of the drug‐loaded HNCaps was extensively evaluated using MTT assay against human breast cancer cells (MCF7). The cytotoxicity assay results as well as superior physicochemical and biological features of the fabricated HNCaps mean that the developed DOX‐loaded HNCaps have excellent potential for cancer chemotherapy. © 2020 Society of Chemical Industry