Premium
Chemically modified xanthan and gellan for preparation of biomaterials for ophthalmic applications
Author(s) -
Hamcerencu Mihaela,
Popa Marcel,
Riess Gerard,
Desbrieres Jacques
Publication year - 2020
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5927
Subject(s) - self healing hydrogels , gellan gum , grafting , acrylic acid , maleic anhydride , acryloyl chloride , polymer chemistry , maleic acid , chemical engineering , rheology , xanthan gum , chemistry , swelling , poly(n isopropylacrylamide) , chemical modification , materials science , copolymer , polymer , organic chemistry , composite material , acrylate , food science , engineering
Gellan and xanthan are extracellular polysaccharides with very interesting rheological or gelling properties. They are esterified with acrylic acid, acryloyl chloride or maleic anhydride. Consequently, due to the presence of carbon double bonds, hydrogels are obtained using a grafting–crosslinking process with N ‐isopropylacrylamide and N ′‐bisacrylamide. Such hydrogels, due to the presence of poly( N ‐isopropylacrylamide), are thermosensitive and present drug release properties which can be adjusted through the reaction conditions. This concept was demonstrated for ophthalmic applications. © 2019 Society of Chemical Industry