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Co‐delivery of methotrexate and doxorubicin via nanocarriers of star‐like poly(DMAEMA‐ block ‐HEMA‐ block ‐AAc) terpolymers
Author(s) -
Saraei Mahnaz,
Sarvari Raana,
Massoumi Bakhshali,
Agbolaghi Samira
Publication year - 2019
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5890
Subject(s) - nanocarriers , methacrylate , materials science , atom transfer radical polymerization , dynamic light scattering , drug delivery , doxorubicin , polymer , polymerization , polymer chemistry , nanotechnology , chemistry , nanoparticle , chemotherapy , medicine , composite material , surgery
Combined therapy is a promising strategy for clinical cancer treatment with synergistic effects. The purpose of the work reported was to evaluate a smart nanocarrier for co‐delivery of doxorubicin (DOX) and methotrexate (MTX). Since star‐like nanocarriers can load a high dose of drugs with various properties, we developed star polymer nanomicelles based on poly[(2,2‐dimethylaminoethyl methacrylate)‐ block ‐(2‐hydroxyethyl methacrylate)‐ block ‐(acrylic acid)] having potential for multi‐drug delivery. The nanomicelles demonstrated high encapsulation efficiency, i.e. 97.1% for DOX and 79.5% for MTX. To this end, the star‐like terpolymers were synthesized via atom transfer radical polymerization with pentaerythritol as an initiator. The micellar properties and dual stimuli‐responsive behaviour of the terpolymers were investigated using transmission electron microscopy, field emission scanning electron microscopy and dynamic light scattering measurements, concluding that this co‐therapy offers a promising approach for cancer treatment. © 2019 Society of Chemical Industry