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Thermal and pH dual‐responsive hydrogels based on semi‐interpenetrating network of poly( N ‐isopropylacrylamide) and collagen nanofibrils
Author(s) -
Ding Cuicui,
Zhang Min,
Ma Miao,
Zheng Jiaojiao,
Yang Qili,
Feng Ren
Publication year - 2019
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5852
Subject(s) - self healing hydrogels , swelling , poly(n isopropylacrylamide) , materials science , differential scanning calorimetry , chemical engineering , polymer , drug delivery , polymer chemistry , thermal stability , polymerization , interpenetrating polymer network , drug carrier , fourier transform infrared spectroscopy , controlled release , copolymer , composite material , nanotechnology , physics , engineering , thermodynamics
Hydrogels with environment‐sensitive properties have great potential applications in the controlled drug release field. In this paper, hybrid hydrogels with semi‐interpenetrating polymer networks (semi‐IPNs), composed of poly( N ‐isopropylacrylamide) (PNIPAM) as the thermo‐sensitive component by in situ polymerization and self‐assembled collagen nanofibrils as the pH‐sensitive framework, were prepared for controlled release of methyl violet as a model drug. From Fourier transform infrared spectroscopy and scanning electron microscopy, it was indicated that the crosslinking of PNIPAM in the presence of collagen nanofibrils led to the formation of semi‐IPNs with homogeneous porous structure, and the semi‐IPNs showed improved thermal stability and elastic properties compared with the native collagen as determined using differential scanning calorimetry and rheologic measurements. Furthermore, the semi‐IPNs possessed swelling behaviors quite different from those of neat collagen or PNIPAM hydrogel under various pH values and temperatures. Correspondingly, as expected, the drug release behavior in vitro for semi‐IPNs performed variously compared with that for single‐component semi‐IPNs, which revealed the tunable performance of semi‐IPNs for release ability. Finally the thermo‐ and pH‐responsive mechanism of the semi‐IPNs was illuminated to provide guidance for the application of the thermo‐ and pH‐sensitive collagen‐based hybrid hydrogels in controlled drug delivery systems. © 2019 Society of Chemical Industry